A unique case of calcinosis in a patient with systemic sclerosis treated with spinal cord stimulation
Published: July 17, 2024
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Systemic sclerosis (SSc) is a complex autoimmune disease presenting with a wide organ-manifestation. One out of three patients with SS is affected by calcinosis, i.e. the deposition of apatite in soft tissue. The association between digital ulcers and calcinosis suggests a role of tissue hypoxia and inflammation in its pathogenesis. Treatment of SSc related ulcers and calcinosis includes immunosuppressive agents, autologous haematopoietic stem cell transplantation, calcium channel blockers, phosphodiesterase 5 inhibitors iloprost or bosentan. Different reports provided promising results about the effect of spinal cord stimulation in the management of digital ulcers, in terms of pain relief and improvement in microcirculation. None of these reports describe the possibility to retrieve calcinosis around the epidural catheter or the pulse generator. The present case report describes a unique case of calcinosis distributed around the pulse generator in a patient with SSc and digital ulcers.
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A unique case of calcinosis in a patient with systemic sclerosis treated with spinal cord stimulation. (2024). Advancements in Health Research, 1(1). https://doi.org/10.4081/ahr.2024.7
Denton CP, Khanna D. Systemic sclerosis. Lancet 2017;390:1685-99. DOI: https://doi.org/10.1016/S0140-6736(17)30933-9
Nitsche A. Raynaud, digital ulcers and calcinosis in scleroderma. Reumatol Clin 2012;8:270-7. DOI: https://doi.org/10.1016/j.reumae.2012.08.001
Pauling JD, Saketkoo LA, Matucci-Cerinic M, et al. The patient experience of Raynaud's phenomenon in systemic sclerosis. Rheumatology (Oxford) 2019;58:18-26. DOI: https://doi.org/10.1093/rheumatology/key026
Gabrielli A, Avvedimento EV, Krieg T. Scleroderma. N Engl J Med 2009;360:1989-2003. DOI: https://doi.org/10.1056/NEJMra0806188
Bartoli F, Fiori G, Braschi F, et al. Calcinosis in systemic sclerosis: subsets, distribution and complications. Rheumatology (Oxford) 2016;55:1610-4. DOI: https://doi.org/10.1093/rheumatology/kew193
Richardson C, Plaas A, Varga J. Calcinosis in systemic sclerosis: updates in pathophysiology, evaluation, and treatment. Curr Rheumatol Rep 2020;22:73. DOI: https://doi.org/10.1007/s11926-020-00951-2
Pope JE, Denton CP, Johnson SR, et al. State-of-the-art evidence in the treatment of systemic sclerosis. Nat Rev Rheumatol 2023;19:212-26. DOI: https://doi.org/10.1038/s41584-023-00909-5
Jerjen R, Nikpour M, Krieg T, et al. Systemic sclerosis in adults. Part II: management and therapeutics. J Am Acad Dermatol 2022;87:957-78. DOI: https://doi.org/10.1016/j.jaad.2021.10.066
Ito H, Tanei T, Sugawara K, et al. Spinal cord stimulation for the treatment of pain and toe ulceration associated with systemic sclerosis: a case report. Fukushima J Med Sci 2022;68:37-41. DOI: https://doi.org/10.5387/fms.2021-33
Provenzano DA, Nicholson L, Jarzabek G, et al. Spinal cord stimulation utilization to treat the microcirculatory vascular insufficiency and ulcers associated with scleroderma: a case report and review of the literature. Pain Med 2011;12:1331-5. DOI: https://doi.org/10.1111/j.1526-4637.2011.01214.x
Puntillo F, Giglio M, Iannone F, et al. Complete relief of a severe feet and hand necrotising Raynaud’s phenomenon with double epidural cervical and dorsal spinal cord stimulation. Ann Case Report 2020;12:289.
Giglio M, Preziosa A, Rekatsina M, et al. Successful spinal cord stimulation for necrotizing Raynaud's phenomenon in COVID-19 affected patient: the nightmare comes back. Cureus 2021;13:e14569. DOI: https://doi.org/10.7759/cureus.14569
van den Hoogen F, Khanna D, Fransen J, et al. 2013 classification criteria for systemic sclerosis: an American College of Rheumatology/European League against Rheumatism collaborative initiative. Arthritis Rheum 2013;65:2737-47. DOI: https://doi.org/10.1002/art.38098
Münster T, Tiebel N, Seyer H, Malhofner C. Modulation of somatosensory profiles by spinal cord stimulation in primary Raynaud's syndrome. Pain Pract 2012;12:469-75. DOI: https://doi.org/10.1111/j.1533-2500.2012.00531.x
Wolter T, Kieselbach K. Spinal cord stimulation for Raynaud’s syndrome: long-term alleviation of bilateral pain with a single cervical lead. Neuromodulation 2011;14:229-34. DOI: https://doi.org/10.1111/j.1525-1403.2011.00332.x
Prager JP. What does the mechanism of spinal cord stimulation tell us about complex regional pain syndrome? Pain Med 2010;11:1278-83. DOI: https://doi.org/10.1111/j.1526-4637.2010.00915.x
Hughes M, Hodgson R, Harris J, et al. Further evidence that calcinosis is associated with repetitive trauma in systemic sclerosis. Semin Arthritis Rheum 2020;50:E4-E5. DOI: https://doi.org/10.1016/j.semarthrit.2019.07.001
Pai S, Hsu V. Are there risk factors for scleroderma-related calcinosis? Mod Rheumatol 2018;28:518-22. DOI: https://doi.org/10.1080/14397595.2017.1349594
Ogawa T, Ogura T, Ogawa K, et al. Paraspinal and intraspinal calcinosis: frequent complications in patients with systemic sclerosis. Ann Rheum Dis 2009;68:1655-6. DOI: https://doi.org/10.1136/ard.2008.104216
How to Cite
A unique case of calcinosis in a patient with systemic sclerosis treated with spinal cord stimulation. (2024). Advancements in Health Research, 1(1). https://doi.org/10.4081/ahr.2024.7
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