https://doi.org/10.4081/ahr.2024.2

Emerging potential therapies for chronic abdominal visceral pain: an overview

Vol. 1 No. 1 (2024)
Published: March 18, 2024
Chronic abdominal pain, cannabinoid, Salbutamol, MOR, 5-HT4 receptors, pomegranate mesocarp, guanylate cyclase-C agonists, vegetal molecules, CGRP, palmitoylethanolamide
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Authors

Martina Rekatsina
mrekatsina@gmail.com
https://orcid.org/0000-0002-7671-4056
Professor of Anesthesia and Pain Management, University of Athens, Greece.
Giustino Varrassi
https://orcid.org/0000-0002-3822-2923
Paolo Procacci Foundation, Rome, Italy.

Despite advancements in pain medicine, management of chronic abdominal visceral discomfort remains a substantial concern for both patients and physicians. Standard pharmacological treatment fails to produce meaningful therapeutic outcomes. As a result, researchers are working on identifying additional modulable targets. Among others, specific receptors (serotonin, α2 adrenergic, cholecystokinin), as well as transient receptor potential vanilloid-1 channel, calcitonin gene-related peptide, mitogen-activated protein kinase and hypothalamic-pituitary-adrenal axis have been proposed as specific targets. Identification of genetic polymorphisms also plays a significant role. In this narrative review, which follows the SANRA criteria, we aimed to present the latest developments of the past five years, in visceral analgesia, without focusing on established pain management modalities. Cannabinoid receptor 2 agonists, high-dose inhaled salbutamol, μ-opioid receptors agonist in acidified microenvironment, 5-HT 4 receptor-antagonist, pomegranate mesocarp, guanylate cyclase-C agonists, assembled system of molecules of vegetal origin, monoclonal antibodies against calcitonin gene-related peptide receptors, palmitoylethanolamide, as well as polydatin micro-RNA based treatments have a possible role in the management of abdominal visceral pain. However, more research is needed because the majority of the findings are based on animal models of visceral pain or preliminary human investigations.

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Rekatsina M, Varrassi G. Emerging potential therapies for chronic abdominal visceral pain: an overview. Adv Health Res [Internet]. 2024 Mar. 18 [cited 2024 Dec. 21];1(1). Available from: https://www.ahr-journal.org/site/article/view/2
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How to Cite

1.
Rekatsina M, Varrassi G. Emerging potential therapies for chronic abdominal visceral pain: an overview. Adv Health Res [Internet]. 2024 Mar. 18 [cited 2024 Dec. 21];1(1). Available from: https://www.ahr-journal.org/site/article/view/2
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